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1221444-51-4

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1221444-51-4 Usage

General Description

"(R)-8-tert-butylchroman-4-amine" is a chemical compound that belongs to the class of amines. It has a tert-butyl group and a chroman moiety, which is a six-membered ring with a benzene ring fused to it. The compound also contains an amine group, which gives it basic properties. The (R) configuration indicates that the molecule has a specific three-dimensional arrangement of substituents around its chiral center. (R)-8-tert-butylchroman-4-amine may have potential uses in pharmaceutical or chemical research due to its unique structure and properties. Further studies and investigations are necessary to explore its potential applications and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 1221444-51-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,4,4 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1221444-51:
(9*1)+(8*2)+(7*2)+(6*1)+(5*4)+(4*4)+(3*4)+(2*5)+(1*1)=104
104 % 10 = 4
So 1221444-51-4 is a valid CAS Registry Number.

1221444-51-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-8-(tert-Butyl)chroman-4-amine

1.2 Other means of identification

Product number -
Other names (4R)-8-tert-butyl-3,4-dihydro-2H-chromen-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1221444-51-4 SDS

1221444-51-4Downstream Products

1221444-51-4Relevant articles and documents

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur

, p. 1338 - 1341 (2011/04/23)

Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.

TRPV1 ANTAGONISTS

-

Page/Page column 105, (2010/04/30)

Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

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