1221446-33-8 Usage
General Description
2-Benzylthiophenylboronic acid is a chemical compound known for its application in various organic and pharmaceutical syntheses. It's categorized as an organoboron compound, with boron having the capability to form stable covalent bonds with other atoms. The compound includes a benzyl group linked with a thiophene, a sulfur-containing heterocycle that has diverse applications in fields like medicinal chemistry. In scientific research, 2-benzylthiophenylboronic acid is used as a component or intermediate in constructing complex molecules because of its functionality and reactivity. It is crucial for scholars studying molecule transformations and interactions in drug development, potentially aiding in the discovery of new medicines.
Check Digit Verification of cas no
The CAS Registry Mumber 1221446-33-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,4,4 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1221446-33:
(9*1)+(8*2)+(7*2)+(6*1)+(5*4)+(4*4)+(3*6)+(2*3)+(1*3)=108
108 % 10 = 8
So 1221446-33-8 is a valid CAS Registry Number.
1221446-33-8Relevant articles and documents
Halogen-lithium exchange versus deprotonation: regioselective mono- and dilithiation of aryl benzyl sulfides. A simple approach to α,2-dilithiotoluene equivalents
Kli?, Tomasz,Serwatowski, Janusz,Wesela-Bauman, Grzegorz,Zadrozna, Magdalena
experimental part, p. 1685 - 1689 (2010/06/13)
Halogen-lithium exchange and deprotonation reactions between aryl benzyl sulfides and alkyllithiums were investigated. The resultant mono- and dilithiated intermediates were converted into the corresponding aldehydes and boronic, or carboxylic acids in good yields. It was found that diethyl ether stabilizes the ortho-lithiated compounds toward isomerisation to the benzylic derivatives. The process occurs easily in THF at low temperature and is a facile route to the α,2-dilithiotoluene derivative which can be transformed into a dicarboxylic acid on treatment with CO2.
