1221576-22-2Relevant academic research and scientific papers
Modular optimization of enantiopure epoxide-derived P,S-ligands for rhodium-catalyzed hydrogenation of dehydroamino acids
Caldentey, Xisco,Cambeiro, Xacobe C.,Perics, Miquel A.
experimental part, p. 4161 - 4168 (2011/06/26)
The optimization of P,S-ligands derived from enantiopure (2S,3S)-phenylglycidol for asymmetric rhodium-catalyzed hydrogenation of dehydroamino esters is described. The exceptionally high modular character of the (2S,3S)-phenylglycidol platform is demonstr
Phosphinite thioethers derived from chiral epoxides. Modular P, S -ligands for pd-catalyzed asymmetric allylic substitutions
Caldentey, Xisco,Pericas, Miquel A.
experimental part, p. 2628 - 2644 (2010/06/17)
A new family of modular P,S-ligands has been prepared from enantiopure arylglycidols. These ligands have been iteratively optimized with respect to four different structural parameters for use in Pd-catalyzed allylic substitutions. As a final output, highly active and enantioselective ligands for these synthetically important transformations have been developed, and the factors controlling their catalytic behavior have been rationalized. From a methodological point of view, a convenient procedure for the regioselective ring-opening of cis-glycidic esters with bulky thiols to yield the corresponding β-alkylthio-α-hydroxy carboxylic acids has been developed.
