1221683-14-2Relevant academic research and scientific papers
Rhodium-catalyzed C-C bond cleavage: Construction of acyclic methyl substituted quaternary stereogenic centers
Seiser, Tobias,Cramer, Nicolai
, p. 5340 - 5341 (2010)
A rhodium-catalyzed enantioselective insertion into the C?C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to methyl substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest saturated hydrocarbon with a quaternary stereogenic center.
