1221684-51-0

Basic information

• Product Name: 2-Bromo-4-fluorostyrene
• Synonyms: 2-Bromo-4-fluorostyrene;2-Bromo-4-fluoro-1-vinylbenzene, 2-Bromo-1-ethenyl-4-fluorobenzene;2-BroMo-4-fluoro-1-vinylbenzene;2-BroMo-1-ethenyl-4-fluorobenzene
• CAS NO: 1221684-51-0
• Molecular Formula: C₈H₆BrF
• Molecular Weight: 201
• Mol File: 1221684-51-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 204.6±20.0℃ (760 Torr)
• Flash Point: 80.2±16.6℃
• Appearance: /
• Density: 1.480±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 2-Bromo-4-fluorostyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluorostyrene(1221684-51-0)
• EPA Substance Registry System: 2-Bromo-4-fluorostyrene(1221684-51-0)

Safety Data

• Hazardous Substances Data: 1221684-51-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-fluorostyrene is a chemical compound with the formula C8H6BrF. It is a derivative of styrene, a compound commonly used in the production of plastics and resins. 2-Bromo-4-fluorostyrene is used as a building block in organic synthesis, particularly in the creation of various pharmaceuticals and fine chemicals. It is a versatile reagent in the formation of carbon-carbon and carbon-heteroatom bonds, and its unique structure lends itself to a variety of reactions and transformations. 2-Bromo-4-fluorostyrene is an important intermediate in the development of many complex organic molecules and has found utility in various research and industrial applications.

Upstream product

• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 2065-66-9 methyl-triphenylphosphonium iodide 

Downstream Products

• 1228180-96-8 5-fluoro-2-vinyl-benzaldehyde 
• 1400743-00-1 C₁₄H₁₉BBrFO₂ 
• 261711-19-7 2-bromo-1-ethyl-4-fluorobenzene 

Relevant articles and documents

An Efficient Synthesis of Benzazocines by Gold(I)-Catalyzed Tandem 1,2-Acyloxy Shift/[3+2] Cycloaddition of Terminal 1,9-Enynyl Esters

An effective synthesis of structurally diverse benzazocines was accomplished in good to excellent chemical yields (55–82 %) through a gold(I)-catalyzed cascade reaction involving tandem 1,2-acyloxy shift/[3+2] cycloaddition of terminal 1,9-enynyl esters. The reaction proceeds under extremely mild conditions and represents one of the relatively few transition-metal-catalyzed intramolecular cycloaddition reactions for the synthesis of benzazocines.

Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation

We herein report the development of a sterically hindered and electron-rich P-chiral monophosphorus biaryl ligand that has enabled a general and efficient enantioselective intramolecular α-arylation, providing access to a wide series of [4.4], [4.5], and [4.6]-spirocycles with chiral benzylic quaternary carbons in high yields with good to excellent enantioselectivities. A pronounced water effect on enantioselectivity is observed.

Direct synthesis of dialkylarylvinylsilane derivatives: Metathesis of dialkylaryl-iso-propenylsilane and its application to tetracyclic silacycle dye synthesis

The metathesis of dialkylarylvinylsilane, which has not been accomplished to date, is achieved using dialkylaryl-iso-propenylsilane as a substrate. In addition, we discovered that the reason why the metathesis of a ruthenium carbene complex and dialkylarylvinylsilane is difficult is the formation of a carbide complex.