1221685-58-0

Basic information

• Product Name: C₂₅H₃₃N₃O
• CAS NO: 1221685-58-0
• Molecular Weight: 391.557
• Mol File: 1221685-58-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₃N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₃N₃O(1221685-58-0)
• EPA Substance Registry System: C₂₅H₃₃N₃O(1221685-58-0)

Safety Data

• Hazardous Substances Data: 1221685-58-0(Hazardous Substances Data)

Upstream product

• 3173-53-3 Cyclohexyl isocyanate 
• 30486-56-7 1-benzhydrylperhydro-1,4-diazepine 

Relevant articles and documents

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach

The present study describes the identification via privileged structure-based approach of the benzhydrylpiperazine moiety as a potential scaffold to develop novel CB1 receptor modulators. Efficient structural optimization of the initial four hit compounds led to a high quality lead series, represented by compound 6c. Compound 6c is a highly potent and selective CB1 receptor inverse agonist that is able to reduce body weight in diet-induced obese Sprague-Dawley rats. The preparation of privileged structure-based library, the progression from hit to lead, the structure-activity relationships in the lead series and in vitro and in vivo activity of compound 6c are discussed.