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1221792-11-5

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1221792-11-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1221792-11-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,7,9 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1221792-11:
(9*1)+(8*2)+(7*2)+(6*1)+(5*7)+(4*9)+(3*2)+(2*1)+(1*1)=125
125 % 10 = 5
So 1221792-11-5 is a valid CAS Registry Number.

1221792-11-5Upstream product

1221792-11-5Relevant articles and documents

N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in yersinia: Novel antivirulence agents

Kim, Oak K.,Garrity-Ryan, Lynne K.,Bartlett, Victoria J.,Grier, Mark C.,Verma, Atul K.,Medjanis, Gabriel,Donatelli, Janice E.,Macone, Ann B.,Tanaka, S. Ken,Levy, Stuart B.,Alekshun, Michael N.

experimental part, p. 5626 - 5634 (2010/02/28)

LcrF, a multiple adaptational response (MAR) transcription factor, regulates virulence in Yersinia pestis and Yersinia pseudotuberculosis. In a search for small molecule inhibitors of LcrF, an acrylic amide series of N-hydroxybenzimidazoles was synthesized and the SAR (structure-activity relationship) was examined. Selected test compounds demonstrated inhibitory activity in a primary cell-free LcrF-DNA binding assay as well as in a secondary whole cell assay (type III secretion system dependent Y. pseudotuberculosis cytotoxicity assay). The inhibitors exhibited no measurable antibacterial activity in vitro, confirming that they do not target bacterial growth. These results demonstrate that N-hydroxybenzimidazole inhibitors, exemplified by 14, 22, and 36, are effective antivirulence agents and have the potential to prevent infections caused by Yersinia spp.

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