1221793-62-9 Usage
General Description
3-Bromo-5-chloropyridine 1-oxide is a chemical compound with the molecular formula C5H3BrClNO. It is a pyridine derivative with a bromine and a chlorine atom attached to the 3rd and 5th position of the pyridine ring, respectively, and an oxygen atom at the 1st position. 3-Bromo-5-chloropyridine 1-oxide is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various biologically active compounds. It has potential applications in the development of pharmaceuticals, agrochemicals, and materials science. 3-Bromo-5-chloropyridine 1-oxide is known for its usefulness in the development of new drugs and is a key intermediate in the synthesis of complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1221793-62-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,7,9 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1221793-62:
(9*1)+(8*2)+(7*2)+(6*1)+(5*7)+(4*9)+(3*3)+(2*6)+(1*2)=139
139 % 10 = 9
So 1221793-62-9 is a valid CAS Registry Number.
1221793-62-9Relevant articles and documents
Nature of the Nucleophilic Oxygenation Reagent Is Key to Acid-Free Gold-Catalyzed Conversion of Terminal and Internal Alkynes to 1,2-Dicarbonyls
Dubovtsev, Alexey Yu.,Shcherbakov, Nikolay V.,Dar'in, Dmitry V.,Kukushkin, Vadim Yu.
, p. 745 - 757 (2020)
2,3-Dichloropyridine N-oxide, a novel oxygen transfer reagent, allows the conductance of the gold(I)-catalyzed oxidation of alkynes to 1,2-dicarbonyls in the absence of any acid additives and under mild conditions to furnish the target species, including those derivatized by highly acid-sensitive groups. The developed strategy is effective for a wide range of alkyne substrates such as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even unsubstituted acetylene (40 examples; yields up to 99%). The oxidation was successfully integrated into the trapping of reactive dicarbonyls by one-pot heterocyclization and into the synthesis of six-membered azaheterocycles. This synthetic acid-free route was also successfully applied for the total synthesis of a natural 1,2-diketone.
