122180-35-2Relevant academic research and scientific papers
A novel synthesis of some new imidazothiazole and glycocyamidine derivatives and studies on their antimicrobial activities
Magd El-Din, Asmaa A.,Roaiah, Hanaa F.,Elsharabasy, Salwa A.,Hassan, Aisha Y.
, p. 529 - 536 (2007)
5,5-diphenyl-2-thioxoimidazolidin-4-one (1) reacted with chloroacetic acid 2a and ethyl chloroacetate 2b in an alkaline medium to afford 2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2 ylthio)acetic acid (3a) and ethyl 2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2 ylthio)acetate (3b), respectively. Compounds 3a,b were converted to 5,5-diphenylimidazolidine-2,4- dione (4) by boiling in ethanolic hydrochloric acid. When compounds 3a,b were treated with polyphosphoric acid, cyclization occurred, and 6,6- diphenylimidazo[2,1-b]thiazole 3,5(2H,6H)-dione (5) was obtained. 2-(methylthio)-1H-imidazol-5(4H)-one derivatives (a,b reacted with hydrazine hydrate to give the corresponding hydrazones 7a,b. The reaction of 6a,b with hydrazine hydrate afforded 3-amino-2-phenylimino imidazolidin-4-one derivatives 10a,b. The antimicrobial activities of compounds 1. 3a,b, 5, 7a,b, and 10a,b were studied. Copyright Taylor & Francis Group, LLC.
Reaction of 5,5-diphenyl-2-thiohydantoin with ethyl chloroacetate: Synthesis and crystal and molecular structure of 2,3,5,6-tetrahydroimidazo--thiazol-3,6-dione
Kiec-Kononowich, Katarzyna,Karolak-Wojciechowska, Janina,Kwiatkowskii, Witold
, p. 563 - 574 (2007/10/02)
The crystal and molecular structure of the title compound, obtained as a result of intramolecular cyclization of 5,5-diphenyl-2-carboxymethylmercaptohydantoin, has been determined from X-ray diffractometer data.The final R was 0.049 for 1869 reflections.T
