1221821-69-7

Basic information

• Product Name: ethyl 5-(naphthalen-3-yl)isoxazole-3-carboxylate
• Synonyms: ethyl 5-(naphthalen-3-yl)isoxazole-3-carboxylate
• CAS NO: 1221821-69-7
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.28
• Mol File: 1221821-69-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-(naphthalen-3-yl)isoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(naphthalen-3-yl)isoxazole-3-carboxylate(1221821-69-7)
• EPA Substance Registry System: ethyl 5-(naphthalen-3-yl)isoxazole-3-carboxylate(1221821-69-7)

Safety Data

• Hazardous Substances Data: 1221821-69-7(Hazardous Substances Data)

Upstream product

• 65356-53-8 2-hydroxy-4-oxo-4-(2-naphthyl)but-2-enoic acid ethyl ester 
• 1221821-73-3 ethyl 5-hydroxy-5-(2-naphthyl)-4,5-dihydro-3-isoxazolecarboxylate 
• 1221821-78-8 ethyl 3-hydroxy-5-(2-naphthyl)-2,3-dihydro-3-isoxazolecarboxylate 
• 264885-11-2 tert-butyldimethyl((1-(naphthalen-2-yl)vinyl)oxy)silane 
• 93-08-3 methyl 2-naphthyl ketone 

Downstream Products

• 1314023-92-1 5-(naphth-2-yl)-N-(3-phenypropyl)isoxazole-3-carboxamide 

Relevant articles and documents

Synthesis of isoxazoles via cyclization of β-fluoro enones with sodium azide

A practical method for the synthesis of 3,5-disubstituted isoxazoles via cyclization of β-fluoro enones with sodium azide was disclosed. Density functional theory (DFT) calculation indicated that both (1) the azirine formation followed by intramolecular rearrangement and (2) direct enolate O-attack via 5-exo-trig cyclization of vinyl azide were possible for the isoxazole formation.

Synthesis of 2,3 and 4,5-dihydro-hydroxy-isoxazoles and isoxazoles under different pH conditions

Reaction between aryl 1,3-diketoesters 2a-e and hydroxylamine hydrochloride has been investigated under different experimental conditions. Whereas acid conditions gave principally 3,5-isoxazole esters (3a-e), reactions under neutral and basic conditions l