1221891-26-4

Basic information

• Product Name: C₂₅H₂₀O₃
• CAS NO: 1221891-26-4
• Molecular Weight: 368.432
• Mol File: 1221891-26-4.mol

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₀O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₀O₃(1221891-26-4)
• EPA Substance Registry System: C₂₅H₂₀O₃(1221891-26-4)

Safety Data

• Hazardous Substances Data: 1221891-26-4(Hazardous Substances Data)

Upstream product

• 86-52-2 1-Chloromethylnaphthalene 
• 1221891-25-3 4-bromo-2-(naphthalen-1-ylmethoxy)benzoic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 22717-56-2 4-bromo-2-Hydroxybenzoic Acid Methylester 

Downstream Products

• 1221890-24-9 3-(naphthalen-1-ylmethoxy)-[1,1^,-biphenyl]-4-carboxylic acid 

Relevant articles and documents

Discovery of novel allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase by integrated lead finding

Farnesyl pyrophosphate synthase (FPPS) is an established target for the treatment of bone diseases, but also shows promise as an anticancer and anti-infective drug target. Currently available anti-FPPS drugs are active-site-directed bisphosphonate inhibitors, the peculiar pharmacological profile of which is inadequate for therapeutic indications beyond bone diseases. The recent discovery of an allosteric binding site has paved the way toward the development of novel non-bisphosphonate FPPS inhibitors with broader therapeutic potential, notably as immunomodulators in oncology. Herein we report the discovery, by an integrated lead finding approach, of two new chemical classes of allosteric FPPS inhibitors that belong to the salicylic acid and quinoline chemotypes. We present their synthesis, biochemical and cellular activities, structure-activity relationships, and provide X-ray structures of several representative FPPS complexes. These novel allosteric FPPS inhibitors are devoid of any affinity for bone mineral and could serve as leads to evaluate their potential in none-bone diseases. Beyond the bone: Farnesyl pyrophosphate synthase (FPPS) is an important target for osteoporosis and bone metastases, and holds promise for a number of non-bone diseases, including cancer, parasitic infections, progeria, and Alzheimer's disease. Herein we describe two novel chemotypes of allosteric FPPS inhibitors. These are useful leads to evaluate the therapeutic potential of FPPS inhibitors for these new indications.

SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS

The invention relates to the use of and mainly novel compounds of the formula (I) wherein the moieties are as defined in the description, which are useful as farnesyl pyrophosphate synthase modulators and e.g. in the treatment of proliferative diseases.