CASPASE-1, also known as interleukin (IL)-1-converting enzyme, is a member of the aspartate-specific cysteine proteases family. It is primarily synthesized as procaspase-1 zymogen and becomes catalytically active post autoproteolysis. The enzymatically active caspase-1 consists of two p20/p10 heterodimers, forming a tetramer. It is mapped to human chromosome 11q22.3 and plays a crucial role in the regulation of inflammation and apoptosis.
122191-40-6
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Basic information
- Product Name: CASPASE-1
- Synonyms: ICE;ICE 1B HUMAN;IL-1BETA CONVERTING ENZYME;INTERLEUKIN-1BETA CONVERTING ENZYME;INTERLEUKIN-1B-CONVERTING ENZYME HUMAN;CASPASE-1 PROTEIN, RECOMBINANT HUMAN ACTIVE;CASPASE 1 HUMAN;CASPASE-1 HUMAN, RECOMBINANT, ACTIVE
- CAS NO:122191-40-6
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: CASPASE-1(CAS DataBase Reference)
- NIST Chemistry Reference: CASPASE-1(122191-40-6)
- EPA Substance Registry System: CASPASE-1(122191-40-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: -
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 122191-40-6(Hazardous Substances Data)
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122191-40-6 Usage
Uses
Used in In Vitro Cleavage Assays:CASPASE-1 is used as an enzyme in in vitro cleavage assays for the study of protein interactions and cleavage patterns. In this application, it is used to cleave Rab interacting lysosomal protein (RILP), providing insights into the molecular mechanisms of protein processing and function.
Used in Cleavage of Caspases-3/7 in Human Monocytic Cells:
CASPASE-1 is also used as a catalyst in the cleavage of caspases-3/7 in human monocytic cells (THP1). This application helps researchers understand the role of CASPASE-1 in the activation of downstream caspases, which are essential for the execution of apoptosis and the regulation of inflammatory responses.
Used in Pharmaceutical Industry:
CASPASE-1 is used as a target for the development of novel therapeutics in the pharmaceutical industry. By modulating the activity of CASPASE-1, researchers can potentially develop treatments for various inflammatory and autoimmune diseases, as well as cancer.
Used in Research and Development:
CASPASE-1 is used as a research tool in the study of cellular processes, such as apoptosis and inflammation. It helps researchers understand the molecular mechanisms underlying these processes and identify potential targets for therapeutic intervention.
Used in Drug Delivery Systems:
CASPASE-1 can be used as a target for the development of novel drug delivery systems, aiming to improve the delivery, bioavailability, and therapeutic outcomes of drugs targeting this enzyme. This application can lead to the development of more effective treatments for diseases associated with CASPASE-1 dysregulation.
Biochem/physiol Actions
Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening.Check Digit Verification of cas no
The CAS Registry Mumber 122191-40-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,1,9 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.Calculate Digit Verification of CAS Registry Number 122191-40:
(8*1)+(7*2)+(6*2)+(5*1)+(4*9)+(3*1)+(2*4)+(1*0)=86
86 % 10 = 6
So 122191-40-6 is a valid CAS Registry Number.
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CASPASE-1
