122191-40-6

Basic information

• Product Name: CASPASE-1
• Synonyms: ICE;ICE 1B HUMAN;IL-1BETA CONVERTING ENZYME;INTERLEUKIN-1BETA CONVERTING ENZYME;INTERLEUKIN-1B-CONVERTING ENZYME HUMAN;CASPASE-1 PROTEIN, RECOMBINANT HUMAN ACTIVE;CASPASE 1 HUMAN;CASPASE-1 HUMAN, RECOMBINANT, ACTIVE
• CAS NO: 122191-40-6
• Molecular Weight: 0
• Mol File: 122191-40-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −70°C
• CAS DataBase Reference: CASPASE-1(CAS DataBase Reference)
• NIST Chemistry Reference: CASPASE-1(122191-40-6)
• EPA Substance Registry System: CASPASE-1(122191-40-6)

Safety Data

• Hazardous Substances Data: 122191-40-6(Hazardous Substances Data)

Usage

Uses

Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocytic?cells (THP1).

General Description

Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer.

Biochem/physiol Actions

Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening.