1221971-43-2

Basic information

• Product Name: C₂₁H₁₅ClN₂O₄S
• CAS NO: 1221971-43-2
• Molecular Weight: 426.88
• Mol File: 1221971-43-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₅ClN₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₅ClN₂O₄S(1221971-43-2)
• EPA Substance Registry System: C₂₁H₁₅ClN₂O₄S(1221971-43-2)

Safety Data

• Hazardous Substances Data: 1221971-43-2(Hazardous Substances Data)

Upstream product

• 5748-36-7 3'-chloro-[1,1'-biphenyl]-4-amine 
• 35511-14-9 methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide 

Relevant articles and documents

Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template

Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE2 inhibition in a cell-based assay (0.42 μM) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF1α.