1221972-24-2Relevant academic research and scientific papers
Iron-Catalyzed Synthesis of α-Dienyl Five- and Six-Membered N-Heterocycles
Gonnard, Laurine,Guérinot, Amandine,Cossy, Janine
, p. 6160 - 6167 (2017/11/15)
The iron-catalyzed synthesis of α-dienyl N-heterocycles is reported. The method is cost-effective, atom-economic, and led to a range of substituted α-dienyl heterocycles in moderate to good yields and diastereoselectivities. The α-dienyl piperidines are key synthetic intermediates as demonstrated by the preparation of a panel of α-polyenyl N-heterocycles.
FeCl3-catalyzed highly diastereoselective synthesis of substituted piperidines and tetrahydropyrans
Guerinot, Amandine,Serra-Muns, Anna,Gnamm, Christian,Bensoussan, Charlelie,Reymond, Sebastien,Cossy, Janine
supporting information; experimental part, p. 1808 - 1811 (2010/10/03)
The eco-friendly and highly diastereoselective synthesis of substituted cis-2,6-piperidines and cis-2,6-tetrahydropyrans is described. The key step of this method is the iron-catalyzed thermodynamic equilibration of 2-alkenyl 6-substituted piperidines and 2-alkenyl 6-substituted tetrahydropyrans allowing the isolation of enriched mixtures of the most stable cis-isomers.
