1222010-73-2Relevant academic research and scientific papers
BORON-CONTAINING SMALL MOLECULES AS ANTI-PROTOZOAL AGENTS
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, (2010/04/30)
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Discovery of novel benzoxaborole-based potent antitrypanosomal agents
Ding, Dazhong,Zhao, Yaxue,Meng, Qingqing,Xie, Dongsheng,Nare, Bakela,Chen, Daitao,Bacchi, Cyrus J.,Yarlett, Nigel,Zhang, Yong-Kang,Hernandez, Vincent,Xia, Yi,Freund, Yvonne,Abdulla, Maha,Ang, Kean-Hooi,Ratnam, Joseline,McKerrow, James H.,Jacobs, Robert T.,Zhou, Huchen,Plattner, Jacob J.
scheme or table, p. 165 - 169 (2010/10/21)
We report the discovery of benzoxaborole antitrypanosomal agents and their structure?activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC5
