1222089-30-6

Basic information

• Product Name: (1R,2R)-7'-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-carboxylic acid
• CAS NO: 1222089-30-6
• Molecular Weight: 526.648
• Mol File: 1222089-30-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R)-7'-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-7'-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-carboxylic acid(1222089-30-6)
• EPA Substance Registry System: (1R,2R)-7'-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-carboxylic acid(1222089-30-6)

Safety Data

• Hazardous Substances Data: 1222089-30-6(Hazardous Substances Data)

Upstream product

• 1222090-56-3 methyl 7'-hydroxy-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-carboxylate 
• 6836-19-7 7-Methoxy-1-tetralone 
• 107727-34-4 1-methylene-7-methoxy-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Discovery and optimization of potent GPR40 full agonists containing tricyclic spirocycles

GPR40 (FFAR1 or FFA1) is a target of high interest being pursued to treat type II diabetes due to its unique mechanism leading to little risk of hypoglycemia. We recently reported the discovery of AM-1638 (2), a potent full agonist of GPR40. In this repor