1222106-45-7Relevant articles and documents
Synthesis method of 4,7-diazaspiro[2.5]octane compound
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Paragraph 0081-0087, (2020/11/26)
The invention discloses a synthesis method of a 4,7-diazaspiro[2.5]octane compound, which comprises the following steps: by using a derivative of 4-methoxybenzyl-(1-(hydroxymethyl) cyclopropyl) carbamate as a raw material, substituting, adding a protecting group, removing the protecting group, and performing reduction to obtain the 4,7-diazaspiro[2.5]octane compound. According to the method disclosed by the invention, a flammable and combustible boron trifluoride diethyl ether adduct with corrosive toxicity is prevented from being used in a synthesis route to carry out a synthesis reaction, and the safety in the synthesis reaction is improved.
Preparation method of 4,7-diazaspiro[2.5]octane derivative
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, (2018/12/13)
The invention provides a preparation method of 4,7-diazaspiro[2.5]octane derivative. The 4,7-diazaspiro[2.5]octane derivative is prepared by taking 1-aminocyclopropane carboxylate as a starting material. The preparation method has the advantages of simple operation steps, stable process conditions, high controllability, high product yield (the four-step reaction yield of compounds shown as formulas II to I can be up to 70 percent), environmental friendliness and the like, and is suitable for large-scale production.
IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE
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, (2011/11/07)
[Problem to be Solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative rep