1222175-37-2Relevant articles and documents
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor
Ducharme, Yves,Blouin, Marc,Brideau, Christine,Chateauneuf, Anne,Gareau, Yves,Grimm, Erich L.,Juteau, Helene,Laliberte, Sebastien,MacKay, Bruce,Masse, Frederic,Ouellet, Marc,Salem, Myriam,Styhler, Angela,Friesen, Richard W.
scheme or table, p. 170 - 174 (2010/10/21)
The discovery of novel and selective inhibitors of human 5-lipoxygenase (5-LO) is described. These compounds are potent, orally bioavailable, and active at inhibiting leukotriene biosynthesis in vivo in a dog PK/PD model. A major focus of the optimization
