122223-41-0

Upstream product

• 122223-36-3 methyl 3(RS),5(SR)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 134538-46-8 1-(4-fluorophenyl)-2-nitropropene 
• 122223-48-7 3-(phenylamino)-4-methylpent-2(E)-enoic acid anilide 
• 122223-65-8 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 122223-66-9 3-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal 
• 122223-64-7 1-phenyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole 
• 122223-62-5 4-(4-fluorophenyl)-2-isopropyl-N,1-diphenyl-1H-pyrrole-3-carboxamide 
• 122223-67-0 methyl 5(RS)-hydroxy-3-oxo-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.