122223-56-7

Upstream product

• 5153-69-5 4-fluoro-β-nitrostyrene 
• 105-45-3 acetoacetic acid methyl ester 
• 62-53-3 aniline 
• 124401-37-2 N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine 

Downstream Products

• 122223-34-1 methyl 3(RS),5(SR)-dihydroxy-7-<1-phenyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 122223-61-4 methyl 5(RS)-hydroxy-3-oxo-7-<1-phenyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 122223-60-3 β-<1-phenyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-acrylonitrile 
• 122223-59-0 3-<1-phenyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal 
• 122223-58-9 1-phenyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 122223-57-8 1-phenyl-2-methyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole 

Relevant academic research and scientific papers

Preparation method of multi-substituted pyrrole compound

The present invention discloses a method for preparing a multi-substituted pyrrole compound, which is an aromatic amine compound shown in formula (I), β - dione compound shown in formula (II), β - nitro aryl vinyl compound shown in formula (III) as raw ma

Novel thermal iminocyclopropene rearrangements: regioselectivity in the synthesis of pyrroles

A novel and readily available method for synthesis of pyrroles possessing substituents with various functional groups has been developed, by means of thermal iminocyclopropene rearrangements. It will provide a novel and readily available access to pyrrole

7(1H-pyrrol-3-YL)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1H-pyrrol-3-YL)-substituted 3,5-dihyroxyhept-anoic acids, their corresponding delta-lactones and salts, their use as medicaments and pharmaceutical products and intermediates

7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I STR1 in which A, B, R1, R2, R3, R4 and R5 have the indicated meanings, and the corresponding δ-lactones of the formula II STR2 processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.