122225-70-1

Basic information

• Product Name: Benzyl (2R)-2-Benzyl-5-tert-butylmercapto-4-oxopentanoate
• Synonyms: Benzyl (2R)-2-Benzyl-5-tert-butylmercapto-4-oxopentanoate
• CAS NO: 122225-70-1
• Molecular Weight: 384.54
• Mol File: 122225-70-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzyl (2R)-2-Benzyl-5-tert-butylmercapto-4-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl (2R)-2-Benzyl-5-tert-butylmercapto-4-oxopentanoate(122225-70-1)
• EPA Substance Registry System: Benzyl (2R)-2-Benzyl-5-tert-butylmercapto-4-oxopentanoate(122225-70-1)

Safety Data

• Hazardous Substances Data: 122225-70-1(Hazardous Substances Data)

Upstream product

• 116129-88-5 benzyl (2R)-2-<(tert-butyloxycarbonyl)methyl>-3-phenylpropionate 
• 75-66-1 2-methylpropan-2-thiol 
• 122225-67-6 benzyl (2R)-2-benzyl-3-<(chloromethyl)carbonyl>propionate 
• 119660-51-4 (2S)-2-morpholin-4-yl-3-phenylpropionic acid 

Relevant articles and documents

PEPTIDYL AMINODIOL RENIN INHIBITORS

A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.

Renin-inhibiting peptidyl heterocycles

A renin inhibiting compound of the formula:*(formula 01)* wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl,(alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.