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122226-03-3

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122226-03-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 122226-03-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,2,2 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 122226-03:
(8*1)+(7*2)+(6*2)+(5*2)+(4*2)+(3*6)+(2*0)+(1*3)=73
73 % 10 = 3
So 122226-03-3 is a valid CAS Registry Number.

122226-03-3Relevant articles and documents

Non-peptide renin inhibitors

-

, (2008/06/13)

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Glaucoma treatment

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, (2008/06/13)

A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: STR1 where A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is Ch2 ; R1 is loweralkyl, cycloalkyl methyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is substituted hydroxyalkyamino.

Potent, Low Molecular Weight Renin Inhibitors Containing a C-Terminal Heterocycle: Hydrogen Bonding at the Active Site

Rosenberg, Saul H.,Dellaria, Joseph F.,Kempf, Dale J.,Hutchins, Charles W.,Woods, Keith W.,et al.

, p. 1582 - 1590 (2007/10/02)

A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl.Molecular modeling suggests that the heterocyclic oxygen hydrogen

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