1222343-72-7Relevant academic research and scientific papers
Synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives as 5-lipoxygenase inhibitors
Suh, Jee Hee,Yum, Eul Kgun,Cho, Young Sik
, p. 573 - 578 (2015)
We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammationrelated diseases including asthma and r
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)
Bursavich, Matthew G.,Parker, Daniel P.,Willardsen, J. Adam,Gao, Zhong-Hua,Davis, Thaylon,Ostanin, Kirill,Robinson, Rosann,Peterson, Ashley,Cimbora, Daniel M.,Zhu, Ju-Fen,Richards, Burt
scheme or table, p. 1677 - 1679 (2010/07/03)
Valosin-containing protein (VCP; also known as p97) is a member of the AAA ATPase family with a central role in the ubiquitin-degradation of misfolded proteins. VCP also exhibits antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. We have discovered that 2-anilino-4-aryl-1,3-thiazoles are potent drug-like inhibitors of this enzyme. The identified compounds show low nanomolar VCP potency, demonstrate SAR trends, and show activity in a mechanism based cellular assay. This series of compounds represents the first steps towards a novel, small molecule VCP inhibitor as a cancer therapeutic.
