1222377-88-9Relevant articles and documents
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: Discovery of macrocyclic histone deacetylase inhibitors
Marcaurelle, Lisa A.,Comer, Eamon,Dandapani, Sivaraman,Duvall, Jeremy R.,Gerard, Baudouin,Kesavan, Sarathy,Lee, Maurice D.,Liu, Haibo,Lowe, Jason T.,Marie, Jean-Charles,Mulrooney, Carol A.,Pandya, Bhaumik A.,Rowley, Ann,Ryba, Troy D.,Suh, Byung-Chul,Wei, Jingqiang,Young, Damian W.,Akella, Lakshmi B.,Ross, Nathan T.,Zhang, Yan-Ling,Fass, Daniel M.,Reis, Surya A.,Zhao, Wen-Ning,Haggarty, Stephen J.,Palmer, Michelle,Foley, Michael A.
, p. 16962 - 16976 (2010)
An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti-aldol reactions were performed to produce four ster
