122245-43-6

Upstream product

• 288-32-4 1H-imidazole 
• 71001-35-9 (2-bromoprop-1-en-1-yl)benzene 
• 54624-37-2 (E)-(2-bromoprop-1-en-1-yl)benzene 
• 21453-89-4 (Z)-(2-bromoprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Iron-catalyzed cross-coupling reaction of vinyl bromides or chlorides with imidazoles in the absence of ligands and additives

Highly effective coupling of imidazoles with (E)-vinyl halides can be achieved by using readily available iron catalysts under ligand-free, copper-free and palladium-free conditions. Coupling of (E)-vinyl bromides led to (Z)-products predominantly, while

CuI-catalyzed cross-coupling reaction of (E)-vinyl bromides with nitrogen-containing heterocycles

An efficient and straightforward copper-catalyzed method allowing vinylation of N-nucleophiles with various substituted (E)-vinyl bromides under palladium-free and ligand-free conditions has taken a high yield (up to 95%). Noteworthy is that the doublebond geometry of these vinyl halides was retained with our protocol.