1222470-40-7

Upstream product

• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 53913-96-5 tert-butyl 2-(bromomethyl)acrylate 

Downstream Products

• 1222470-55-4 (R)-tert-butyl 1-benzyl-3-(3-methylbenzyl)-4-oxopyrrolidine-3-carboxylate 
• 1222470-48-5 (S)-tert-butyl 1-benzyl-3-(4-methylbenzyl)-4-oxopyrrolidine-3-carboxylate 
• 1222470-45-2 (S)-tert-butyl 1-benzyl-3-(4-methoxybenzyl)-4-oxopyrrolidine-3-carboxylate 
• 1222470-50-9 (S)-tert-butyl-3-(4-(methylthio)benzyl)-1-benzyl-4-oxopyrrolidine-3-carboxylate 
• 1222470-49-6 (R)-tert-butyl 1-benzyl-3-(3-chloro-4-methoxybenzyl)-4-oxopyrrolidine-3-carboxylate 
• 1222470-47-4 (S)-tert-butyl 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-benzyl-4-oxopyrrolidine-3-carboxylate 

Relevant academic research and scientific papers

Catalytic enantioselective Dieckmann-type annulation: Synthesis of pyrrolidines with quaternary stereogenic centers

A new trick for an old dog: A Dieckmanntype cycllzation was used to synthesize the title compounds with up to 96% ee (see scheme; Bn = benzyl). The presence of a β coordinating functionality in the substrate Induces a competition between cycllzation and elimination pathways that Is influenced by the nature of the chiral llgand. A mechanistic rationale Is proposed to account for these observations.