1222490-63-2Relevant academic research and scientific papers
Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate
Howard, Philip W.,Chen, Zhizhi,Gregson, Stephen J.,Masterson, Luke A.,Tiberghien, Arnaud C.,Cooper, Nectaroula,Fang, Min,Coffils, Marissa J.,Klee, Sarah,Hartley, John A.,Thurston, David E.
scheme or table, p. 6463 - 6466 (2010/06/11)
A prodrug form (17) of a novel C2/C2′-aryl-substituted pyrrolobenzodiazepine (PBD) dimer (16) has been synthesized by introducing sodium bisulfite groups to the C11/C11′-positions of the parent bis-imine. The prodrug form is highly water soluble, stable in aqueous conditions, and the rate of DNA cross-link formation is much slower compared to the parent bis-imine.
