1222509-01-4Relevant academic research and scientific papers
Discovery and structure-activity relationships of 6-(benzoylamino) benzoxaboroles as orally active anti-inflammatory agents
Akama, Tsutomu,Dong, Chen,Virtucio, Charlotte,Freund, Yvonne R.,Chen, Daitao,Orr, Matthew D.,Jacobs, Robert T.,Zhang, Yong-Kang,Hernandez, Vincent,Liu, Yang,Wu, Anne,Bu, Wei,Liu, Liang,Jarnagin, Kurt,Plattner, Jacob J.
, p. 5870 - 5873 (2013/10/22)
Structure-activity relationships of 6-(benzoylamino)benzoxaborole analogs were investigated for the inhibition of TNF-α, IL-1β, and IL-6 from lipopolysaccharide stimulated peripheral blood mononuclear cells. Compound 1q showed potent activity against all three cytokines with IC50 values between 0.19 and 0.50 μM, inhibited LPS-induced TNF-α and IL-6 elevation in mice and improved collagen-induced arthritis in mice. Compound 1q (AN4161) is considered to be a promising lead for novel anti-inflammatory agent with an excellent pharmacokinetic profile.
BORON-CONTAINING SMALL MOLECULES AS ANTI-PROTOZOAL AGENTS
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Page/Page column 104, (2010/04/30)
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
