122252-68-0

Upstream product

• 122252-53-3 2-Acetyl-3-(4-chloro-phenyl)-5-oxo-hexanoic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 3160-40-5 4-(4-chlorophenyl)-3-buten-2-one 
• 14205-39-1 methyl 3-aminocrotonate 

Downstream Products

• 122252-97-5 [4-(4-Chloro-phenyl)-2,6-dimethyl-pyridin-3-yl]-methanol 
• 122253-20-7 3-Bromomethyl-4-(4-chloro-phenyl)-2,6-dimethyl-pyridine 
• 122254-05-1 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-chloro-phenyl)-2,6-dimethyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one 
• 122253-85-4 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-chloro-phenyl)-2,6-dimethyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol 
• 122253-43-4 [4-(4-Chloro-phenyl)-2,6-dimethyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 
• 122253-64-9 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-chloro-phenyl)-2,6-dimethyl-pyridine 
• 123930-15-4 3-{(E)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-chloro-phenyl)-2,6-dimethyl-pyridine 

Relevant academic research and scientific papers

Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

A new method for synthesizing polyalkylated/arylated nicotinates is established using a condensation of enamino esters with enones in the presence of FeCl3. This method facilitates the introduction of alkyl or aryl groups at any position on demand, which has not been achieved by other procedures.

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)