122252-75-9

Upstream product

• 102692-35-3 4,4'-difluorochalcone 
• 122252-61-3 2-[1,3-Bis-(4-fluoro-phenyl)-3-oxo-propyl]-4-methyl-3-oxo-pentanoic acid ethyl ester 

Downstream Products

• 122253-05-8 [4,6-Bis-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-methanol 
• 123837-69-4 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4,6-bis-(4-fluoro-phenyl)-2-isopropyl-pyridine 
• 122253-50-3 [4,6-Bis-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 
• 122253-91-2 (4R,6S)-6-{(E)-2-[4,6-Bis-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol 
• 122287-19-8 (4R,6S)-6-{(E)-2-[4,6-Bis-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one 
• 122253-28-5 3-Bromomethyl-4,6-bis-(4-fluoro-phenyl)-2-isopropyl-pyridine 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)