122254-22-2

Upstream product

• 122253-95-6 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-ol 
• 122253-33-2 5-Bromomethyl-4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidine 
• 122253-10-5 [2-phenyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-5-yl]-methanol 
• 122252-89-5 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine 
• 123930-30-3 5-{(E)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidine 
• 1670-14-0 benzamidine monohydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 122253-54-7 [4-(4-Fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-ylmethyl]-triphenyl-phosphonium; bromide 
• 122930-46-5 1,4-dihydro-4-(4-fluorophenyl)-2-isopropyl-6-phenylpyrimidine-3-carboxylic acid ethyl ester 

Downstream Products

• 122254-59-5 (4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)