122254-61-9Relevant academic research and scientific papers
Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids
Beck, G.,Kesseler, K.,Baader, E.,Bartmann, W.,Bergmann, A.,et al.
, p. 52 - 60 (2007/10/02)
Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)
6-(((SUBSTITUTED)PYRIDIN-3-YL)ALKYL)-AND ALKENYL)-TETRAHYDRO-4-HYDROXYPYRAN-2-ONE INHIBITORS OF CHOLESTEROL BIOSYNTHESIS
-
, (2008/06/13)
Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl-and alkenyl] tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reducta
