122263-36-9Relevant academic research and scientific papers
Phenylsulfonylnitromethanes as potent irreversible inhibitors of aldose reductase
Saab, Nada H.,Donkor, Isaac O.,Rodriguez, Libaniel,Kador, Peter F.,Miller, Duane D.
, p. 745 - 751 (2007/10/03)
Aldose reductase (AR) inhibition provides a viable pharmacologically direct mode for the treatment of diabetic complications. We have synthesized a series of N-4 substituted analogues (15-21) of the known aldose reductase inhibitor phenyl-sulfonylnitromethane. The compounds are potent inhibitors of AR with IC50s between 0.01 and 0.19 μM. Some of the compounds are also potent affinity labels for AR. Compound 19 exhibits the highest and almost complete irreversible inhibition of AR known to date.
PHENYLSULFONYL NITROMETHANES AS ALDOSE REDUCTASE INHIBITORS
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, (2008/06/13)
The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic salt) as active ingredient. The nitromethane derivatives
