122278-39-1Relevant articles and documents
Radical cyclizations in 1,4-dimethylpiperazine
Ishibashi, Hiroyuki,Haruki, Shigeki,Uchiyama, Masahiko,Tamura, Osamu,Matsuo, Jun-ichi
, p. 6263 - 6266 (2006)
N-Allylic or N-vinylic α,α,α-trichloroacetamides, upon heating in 1,4-dimethylpiperazine, undergo radical cyclization to give the corresponding γ-lactams.
Synthesis of α-Chlorolactams by Cyanoborohydride-Mediated Radical Cyclization of Trichloroacetamides
Coussanes, Guilhem,Jakobi, Harald,Lindell, Stephen,Bonjoch, Josep
supporting information, p. 8151 - 8156 (2018/05/30)
A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way using NaBH3CN and trichloroacetamides easily available from allylic and homoallylic secondary amines. This methodology allowed the synthesis of a library of α-chlorolactams (mono- and bicyclic), which were tested for herbicidal activity, trans-3-chloro-4-methyl-1-(3-trifluoromethyl)phenyl-2-pyrrolidinone being the most active.
Synthesis of Five-membered Lactams by α-Carbamoyl Radical Cyclisations
Sato, Tatsunori,Wada, Yasuko,Nishimoto, Mami,Ishibashi, Hiroyuki,Ikeda, Masazumi
, p. 879 - 886 (2007/10/02)
Free-radical cyclisation of N-allyl-α-carbamoyl radicals generated by tributyltin radical-mediated cleavage of carbon-chlorine or carbon-sulphur bonds has been studied in some detail.The radicals substituted at the α position by methylthio (phenylthio), c