1222804-01-4Relevant academic research and scientific papers
INDOLE COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC RECEPTOR
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Page/Page column 251; 260, (2012/01/14)
In one aspect, the invention relates to indole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for ma
Discovery and optimization of a novel, selective and brain penetrant M 1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe
Reid, Paul R.,Bridges, Thomas M.,Sheffler, Douglas J.,Cho, Hyekyung P.,Lewis, L. Michelle,Days, Emily,Daniels, J. Scott,Jones, Carrie K.,Niswender, Colleen M.,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.,Wood, Michael R.
, p. 2697 - 2701 (2011/06/20)
This Letter describes a chemical lead optimization campaign directed at VU0108370, a weak M1 PAM hit with a novel chemical scaffold from a functional HTS screen within the MLPCN. An iterative parallel synthesis approach rapidly established SAR
