1222844-06-5Relevant academic research and scientific papers
Development of new stereodiverse diaminocyclitols as inhibitors of influenza virus neuraminidase
Cui, Yi,Jiao, Zhaodong,Gong, Jianxian,Yu, Quan,Zheng, Xiaofeng,Quan, Junmin,Luo, Ming,Yang, Zhen
supporting information; experimental part, p. 4 - 7 (2010/03/03)
"Chemical Equation Presented" A concise and modular approach to synthesize a new type of cyclopentene-based diaminocyclitol library from D-serine and L-serine has been developed, and key steps in this synthesis are an aza-Claisen rearrangement, a ring-closing metathesis, and a Baylis-Hillman reaction. The developed chemistry may offer a unique way to investigate the neuraminidase (NA) mutation by systematically mapping the changes within its binding sites.
