122287-15-4

Upstream product

• 123930-25-6 2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine 
• 1608-51-1 4-fluorochalcone 
• 123837-50-3 2-[1-(4-Fluoro-phenyl)-3-oxo-3-phenyl-propyl]-4,4-dimethyl-3-oxo-pentanoic acid ethyl ester 
• 122252-72-6 2-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester 
• 122253-25-2 3-Bromomethyl-2-tert-butyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine 
• 122253-02-5 2-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-6-phenyl-3-pyridine methanol 
• 17094-34-7 ethyl pivaloylacetate 
• 122253-47-8 [2-tert-Butyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 

Downstream Products

• 122254-12-0 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[2-tert-butyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)