1223002-54-7 Usage
Description
9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one, also known as BAY-678, is a benzonaphthyridine compound with significant pharmaceutical potential. It functions as a potent inhibitor of DNA topoisomerase I, a crucial enzyme in DNA replication and transcription processes. 9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one has garnered attention for its ability to impede DNA replication in cancer cells, thereby inducing cell death, and for its potential as an antibacterial agent by inhibiting bacterial DNA topoisomerases. The ongoing research into BAY-678's therapeutic capabilities suggests it may contribute to the development of novel treatments for cancer and bacterial infections.
Uses
Used in Pharmaceutical Industry:
9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one is used as an anti-cancer agent for its capacity to disrupt the DNA replication process in cancerous cells, leading to their death. This makes it a promising candidate for the development of new cancer therapies.
Used in Antibacterial Applications:
In the field of antibacterial research, 9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one is utilized as an inhibitor of bacterial DNA topoisomerases, which can potentially lead to the development of new antibiotics to combat bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 1223002-54-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,3,0,0 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1223002-54:
(9*1)+(8*2)+(7*2)+(6*3)+(5*0)+(4*0)+(3*2)+(2*5)+(1*4)=77
77 % 10 = 7
So 1223002-54-7 is a valid CAS Registry Number.
1223002-54-7Relevant articles and documents
SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF
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Page/Page column 163, (2010/04/30)
The present invention relates to small molecule modulators of mTORCl and mT0RC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORCl, mT0RC2, and PI3K-related proteins. Novel methods of providing soluble mTORCl and mT0RC2 complexes are discussed, as well as methods of using the soluble complexes in a high- throughput manner to screen for inhibitory compounds.
