1223020-29-8

Basic information

• Product Name: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine
• Synonyms: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine;PyBidine;2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine
• CAS NO: 1223020-29-8
• Molecular Formula: C₄₉H₄₅N₅
• Molecular Weight: 703.9151
• Mol File: 1223020-29-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• Storage Temp.: <0°C
• PKA: 7.02±0.70(Predicted)
• CAS DataBase Reference: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine(1223020-29-8)
• EPA Substance Registry System: 2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenyliMidazolidin-2-yl]pyridine(1223020-29-8)

Safety Data

• Hazardous Substances Data: 1223020-29-8(Hazardous Substances Data)

Usage

Uses

2,6-Bis[(2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl]pyridine (CAS# 1223020-29-8) is a versatile organic catalyst used in a variety of reactions such as asymmetric Friedel-Crafts reactions, and the preparation of chiral quaternary N,O-acetals.

Upstream product

• 5431-44-7 2,6-Pyridinedicarboxaldehyde 
• 1207290-26-3 (1S,2S)-N₁-benzyl-1,2-diphenylethane-1,2-diamine 

Relevant articles and documents

Chiral bis(imidazolidine)pyridine-Cu(OTf)2: Catalytic asymmetric endo-selective [3 + 2] cycloaddition of imino esters with nitroalkenes

The novel C2-symmetric bis(imidazolidine)pyridine (PyBidine) ligand was easily synthesized in a single condensation of 2,6-pyridyl aldehyde and optically active (S,S)-diphenylethylenediamine. In the C2- symmetric PyBidine?Cu(OTf)2 complex, imidazolidine rings act as chiral fences to shield the first and third quadrants. Use of the PyBidine?Cu(OTf)2 complex as a catalyst enabled the highly endo-selective reaction of imino esters and nitroalkenes to give the adducts in up to 99% ee.