1223091-53-9Relevant academic research and scientific papers
Catalytic asymmetric 1,4-additions of β-keto esters to nitroalkenes promoted by a bifunctional homobimetallic Co2-schiff base complex
Furutachi, Makoto,Chen, Zhihua,Matsunaga, Shigeki,Shibasaki, Masakatsu
, p. 532 - 544 (2010)
Catalytic asymmetric 1,4-addition of β-keto esters to nitroalkenes is described. 2.5 mol % of a homobimetallic Lewis acid/Bronsted base bifunctional Co2-Schiff base complex smoothly promoted the reaction in excellent yield (up to 99%), diastereoselectivity, and enantioselectivity (up to >30:1 dr and 98% ee). Catalyst loading was successfully reduced to 0.1 mol %. Mechanistic studies suggested that intramolecular cooperative functions of the two Co-metal centers are important for high catalytic activity and stereoselectivity.
