1223105-51-8

Basic information

• Product Name: FMoc-α-Me-Phe(2,6-DiF)-OH
• Synonyms: FMoc-α-Me-Phe(2,6-DiF)-OH;Fmoc-alpha-Me-L-Phe(2,6-F2)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-difluorophenyl)-2-methylpropanoic acid;(9H-Fluoren-9-yl)MethOxy]Carbonyl Alpha-Methyl-Phe(2,6-DiF)-OH;Fmoc-alfa-Me-Phe(2,6-diF)-OH
• CAS NO: 1223105-51-8
• Molecular Formula: C₂₅H₂₁F₂NO₄
• Molecular Weight: 437.4353464
• Product Categories: α-Methyl Amino Acids
• Mol File: 1223105-51-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: FMoc-α-Me-Phe(2,6-DiF)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMoc-α-Me-Phe(2,6-DiF)-OH(1223105-51-8)
• EPA Substance Registry System: FMoc-α-Me-Phe(2,6-DiF)-OH(1223105-51-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• TSCA: No
• Hazardous Substances Data: 1223105-51-8(Hazardous Substances Data)

Usage

General Description

FMoc-α-Me-Phe(2,6-DiF)-OH is a chemical compound that consists of a fluorenylmethoxycarbonyl (FMoc) protecting group attached to an alpha-methyl-phenylalanine (α-Me-Phe) molecule with two fluorine atoms at the 2 and 6 positions (2,6-DiF) on the phenyl ring. FMoc-α-Me-Phe(2,6-DiF)-OH is often used in peptide synthesis as a building block for creating peptides with specific structural and functional properties. The FMoc protecting group is commonly used in solid-phase peptide synthesis to protect the N-terminal amine group of the peptide chain, while the α-Me-Phe residue contributes to the hydrophobicity and stereochemical properties of the resulting peptide. The addition of the fluorine atoms at specific positions on the phenyl ring can further modify the properties of the peptide, making it a valuable tool for designing and synthesizing peptides for various research and therapeutic applications.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 516521-28-1 His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2,6-difluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2 

Relevant articles and documents

Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity

Glucagon-like peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological regulation of glucose homeostasis and food intake. Herein, we report the discovery of a novel class of 11 amino acidGLP-1 receptor agonists. These peptides consist of a structurally optimized 9- mer, which is closely related to the N-terminal 9 amino acids ofGLP-1, linked to a substituted C-terminal biphenylalanine (BIP) dipeptide. SAR studies resulted in 11-mer GLP-1R agonists with similar in vitro potency to the native 30-mer. Peptides 21 and 22 acutely reduced plasma glucose excursions and increased plasma insulin concentrations in a mouse model of diabetes. These peptides also showed sustained exposures over several hours in mouse and dog models. The described 11-mer GLP-1 receptor agonists represent a new tool in further understanding GLP-1 receptor pharmacology that may lead to novel antidiabetic agents.