1223105-85-8

Basic information

• Product Name: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione
• Synonyms: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione
• CAS NO: 1223105-85-8
• Molecular Formula: C₁₃H₇F₆NO₃
• Molecular Weight: 339.1899992
• Mol File: 1223105-85-8.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione(1223105-85-8)
• EPA Substance Registry System: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione(1223105-85-8)

Safety Data

• Hazardous Substances Data: 1223105-85-8(Hazardous Substances Data)

Upstream product

• 16588-74-2 3,5-ditrifluoromethylisocyanate 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Downstream Products

• 1570357-01-5 C₁₈H₁₀F₆N₂O₂ 

Relevant articles and documents

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans

A dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavagevia O- toC-lithium transfer. This distinct mode of ring scission gives access to 2-oxobut-3-enamides and tetrasubstituted furans.

Squaramide-catalysed enantionselective Mannich reaction of imines bearing a heterocycle with malonates

An efficient enantioselective Mannich reaction of imines bearing a heterocycle with malonates catalysed by a cinchona-based squaramide organocatalyst has been developed. This catalytic asymmetric reaction afforded the β-amino ester derivatives containing

Catalytic asymmetric cycloetherification via intramolecular oxy-Michael addition of enols

Carbonyl compounds employed as carbon nucleophiles have played a dominant role in synthetic organic chemistry; however, there is very limited use of these compounds as oxygen nucleophiles. In particular, there are only a few reports on the oxy-Michael addition of the enol forms of carbonyl nucleophiles. In this study, we present the asymmetric cycloetherification of enols, which are generated in situ from enone-bearing ketones, using chiral bifunctional organocatalysts bearing amino and squaramide groups. This transformation chemo- and enantioselectively afforded dihydropyran derivatives, which are the core structures of building blocks for synthesizing glycans.