122314-70-9

Upstream product

• 104621-21-8 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetic acid tert-butyl ester 
• 93423-85-9 (2-Methyl-4-oxo-cyclohex-2-enyl)-acetic acid tert-butyl ester 
• 58775-59-0 (4-Ethoxy-2-oxo-cyclohex-3-enyl)-acetic acid tert-butyl ester 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 

Downstream Products

• 104621-22-9 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetaldehyde 

Relevant academic research and scientific papers

Total Synthesis of ( +/-)-Cortisone. Double-Hydroxylation Reaction for Corticoid Synthesis

Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.