1223434-15-8

Basic information

• Product Name: Methyl 4-bromo-2-cyanobenzoate
• Synonyms: Methyl 4-bromo-2-cyanobenzoate
• CAS NO: 1223434-15-8
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.05344
• Mol File: 1223434-15-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 346.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.60±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 4-bromo-2-cyanobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-bromo-2-cyanobenzoate(1223434-15-8)
• EPA Substance Registry System: Methyl 4-bromo-2-cyanobenzoate(1223434-15-8)

Safety Data

• Hazardous Substances Data: 1223434-15-8(Hazardous Substances Data)

Usage

General Description

Methyl 4-bromo-2-cyanobenzoate is a chemical compound with the molecular formula C9H6BrNO2. It is an ester consisting of a methyl group attached to a 4-bromo-2-cyanobenzoate. methyl 4-bromo-2-cyanobenzoate is commonly used as a building block in organic synthesis and is known for its role as an intermediate in the production of pharmaceuticals and agrochemicals. Methyl 4-bromo-2-cyanobenzoate is also used in the manufacturing of dyes, pigments, and other fine chemicals. It is important to handle this compound with care, as it can be toxic and may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 1133123-02-0 4-bromo-2- iodobenzoic acid 
• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 1093418-75-7 methyl 4-bromo-2-iodobenzoate 

Downstream Products

• 1223434-16-9 4-bromo-2-cyanobenzoic acid 

Relevant articles and documents

RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE

Bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (Raf, such as c-Raf, A-Raf, and/or B-Raf), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds Raf, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

CYCLIC AMIDE DERIVATIVE

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C6-10 arylene, etc.; R1a, R1b and R1c each independently is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, etc.; R2 is an optionally substituted C6-10 aryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted C7-16 aralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.)