1223456-23-2Relevant academic research and scientific papers
Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway
Chamberlain, Stanley D.,Redman, Aniko M.,Patnaik, Samarjit,Brickhouse, Keith,Chew, Yen-Chiat,Deanda, Felix,Gerding, Roseanne,Lei, Huangshu,Moorthy, Ganesh,Patrick, Mark,Stevens, Kirk L.,Wilson, Joseph W.,Brad Shotwell
, p. 373 - 377 (2009)
Initial evaluation of a series 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines revealed a C(1′) carboxamide was preferred for sub-micromolar in vitro potency against IGF-1R. Subsequent solution stability studies with 1 revealed a susceptibility toward acid-i
