1223498-32-5

Basic information

• Product Name: (RS)-S-ethyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]amino}-5-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)sulfoximide
• CAS NO: 1223498-32-5
• Molecular Weight: 417.455
• Mol File: 1223498-32-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-S-ethyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]amino}-5-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)sulfoximide(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-S-ethyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]amino}-5-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)sulfoximide(1223498-32-5)
• EPA Substance Registry System: (RS)-S-ethyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]amino}-5-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)sulfoximide(1223498-32-5)

Safety Data

• Hazardous Substances Data: 1223498-32-5(Hazardous Substances Data)

Upstream product

• 1223498-63-2 (R,S)-S-(4-aminophenyl)-S-ethyl-N-(trifluoroacetyl)sulfoximide 
• 1223498-62-1 (R,S)-S-ethyl-S-(4-nitrophenyl)-N-(trifluoroacetyl)sulfoximide 
• 7205-70-1 (R,S)-1-(ethylsulfinyl)-4-nitrobenzene 
• 7205-60-9 1-(ethylsulfanyl)-4-nitrobenzene 
• 3932-97-6 2,4-dichloro-5-trifluoromethylpyrimidine 

Relevant articles and documents

The lab oddity prevails: Discovery of Pan-CDK inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY1000394) for the treatment of cancer

Lead optimization of a high-throughput screening hit led to the rapid identification of aminopyrimidine ZK304709, a multitargeted CDK and VEGF-R inhibitor that displayed a promising preclinical profile. Nevertheless, ZK304709 failed in phaseI studies due