122376-69-6Relevant articles and documents
Palladium-catalyzed direct deprotonative arylation of 2-pyridylacetonitriles: Facile synthesis of alpha-aryl-2-pyridylacetonitrile
Yin, Bo,Du, Yu-Feng,Chen, Yan-Zuo,Li, Xiaohuan,Fang, Dong-Mei,Gao, Feng
, (2020)
α-Aryl-2-pyridylacetonitrile, an important chemical intermediate, was synthesized via direct deprotonative arylation of 2-pyridylacetonitrile with aryl bromides. Pd(OAc)2/NixantPhos-based catalysis system promoted this arylation reaction to furnish divers
Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines
Buschauer, Armin
, p. 165 - 171 (2007/10/02)
Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.