122376-90-3

Basic information

• Product Name: 5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-pentanenitrile
• Synonyms: 5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-pentanenitrile
• CAS NO: 122376-90-3
• Molecular Weight: 381.434
• Mol File: 122376-90-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-pentanenitrile(122376-90-3)
• EPA Substance Registry System: 5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-pentanenitrile(122376-90-3)

Safety Data

• Hazardous Substances Data: 122376-90-3(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 109-09-1 2-chloropyridine 
• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 

Downstream Products

• 106670-61-5 4-phenyl-4-(pyrid-2-yl)-butylamine 

Relevant articles and documents

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.