1224048-15-0Relevant articles and documents
Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity
Liu, Kevin K.-C.,Lefker, Bruce A.,Dombroski, Mark A.,Chiang, Phoebe,Cornelius, Peter,Patterson, Terrell A.,Zeng, Yuan,Santucci, Stephanie,Tomlinson, Elizabeth,Gibbons, Colleen P.,Marala, Ravi,Brown, Janice A.,Kong, Jimmy X.,Lee, Eunsun,Werner, Wendy,Wenzel, Zane,Giragossian, Craig,Chen, Hou,Coffey, Steven B.
scheme or table, p. 2365 - 2369 (2010/09/03)
Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor. After medicinal chemistry optimization and SAR studies, orally active proline amides with robust efficacy in a rodent foo