1224095-98-0 Usage
Enzyme inhibitor
This membrane-lyzing defensin mimetic (FW = 932.98 g/mol; CAS 1224095-98-0; IUPAC: N,N’-bis[3-{[5-(carbamimidoylamino)pentanoyl] amino}-2-[(3R)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)phenyl]pyrimidine- 4,6-dicarboxamide)) is bactericidal (not simply bacteriostatic like most antibiotic) toward a broad spectrum of bacteria, but not mammalian cells. Brilacidin kills many Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium as well as Gramnegative bacteria, including Eschericia coli and Klebsiella pneumonia (NDM). This action of this drug commend it for use in controlling Acute Bacterial Skin and Skin Structure Infections (ABSSSI). A five-day treatment course is usually effective in the treatment of many infections, and, given its direct membrane-disrupting action, bacteria are highly unlikely to acquire resistance to brilacidin.
Check Digit Verification of cas no
The CAS Registry Mumber 1224095-98-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,4,0,9 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1224095-98:
(9*1)+(8*2)+(7*2)+(6*4)+(5*0)+(4*9)+(3*5)+(2*9)+(1*8)=140
140 % 10 = 0
So 1224095-98-0 is a valid CAS Registry Number.
1224095-98-0Relevant articles and documents
Synthetic Mimetics Of Host Defense And Uses Thereof
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Page/Page column 14; 15; 16, (2010/05/13)
The present invention provides arylamide compounds and methods of making and using them as antibiotics.
